Muscleboy looking for a dom keen to turn him into a musclefreak

[joxok]

as above...

[CelticMuscle]

Taken from New Scientist, December 2005

THANKS to research on "mighty mice", the lives of people suffering from muscle-wasting diseases such as muscular dystrophy could be transformed. Two treatments that block a protein called myostatin, which slows muscle growth, are now in the pipeline.

The first approach, announced this week, aims to use a drug to mop up myostatin. Meanwhile a second method, which is already in clinical trials in people with muscular dystrophy, uses antibodies to disable the protein.

In 1997, researchers led by Se-Jin Lee of Johns Hopkins University School of Medicine in Baltimore, Maryland, engineered mice in which the gene for myostatin had been "knocked out". The animals grew muscles twice as big as normal. A defect in the myostatin gene was what caused a German toddler, whose story was widely publicised last year, to develop prodigious muscles.

Now Lee has produced a soluble molecule called activin type IIB receptor (ACVR2B) that binds to myostatin in normal mice, causing their muscles to bulk up. He hopes ACVR2B can be used to treat conditions such as Duchenne muscular dystrophy, a genetic disease that affects 1 in 3000 boys. Their muscles waste away because of a defect in the gene for the protein dystrophin, which is important in organising muscle structure.

"It is an exceptionally promising study," says Kay Davies, who studies the genetics of Duchenne muscular dystrophy at the University of Oxford. "For the first time we have a real hope of treating the disease."

Lee's team gave different amounts of ACVR2B to 49 mice and measured muscle development after one to four weeks. The greatest impact on muscle growth was with two injections a week apart, at a dose of 50 milligrams per kilogram of body weight. These mice increased their muscle mass by up to 61 per cent (Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.0505996102).

The mice developed normally and appeared unchanged apart from their muscles. But the researchers want to do further checks to see whether the drug affects other tissues. One worry is that it might affect heart muscle, causing the organ to become dangerously enlarged. Another question is whether treatment with ACVR2B will work in the long term. Davies points out that, over time, the drug might exhaust the supply of the precursor cells that give rise to muscle.

Engineered mice in which the gene for myostatin had been 'knocked out' grew muscles twice as big as normal
However, the pharmaceutical company Wyeth in Cambridge, Massachusetts, is already performing clinical trials of another myostatin blocker on more than 100 patients with muscular dystrophy. Wyeth is testing an antibody that binds to myostatin and stops it working. The company hopes to have initial results by late 2006.

Another worry is that drugs like ACRVB2 might be abused by athletes and body builders. Some websites already sell compounds that purport to boost muscle strength by blocking myostatin. But it should be possible for anti-doping agencies to develop a test. ACVR2B is not usually present in the blood in large quantities. And the version used by Lee is a conspicuously artificial "hybrid" molecule containing part of another protein.

It is an exceptionally promising study. For the first time we have a real hope of treating Duchenne muscular dystrophy
If ACVR2B is abused, a test may be important not just to keep sport clean but also to stop supplies being diverted from patients who really need the drug. "People who abuse such technology are only depriving others who are truly in medical need," says Lee.

[redwolf64]

Is there anything using ACRVB2 available yet "under the counter"? I haven't seen anything confirming that it actually works or that it's filtering out to the public.

[joxok]

Originally Posted by redwolf64

Is there anything using ACRVB2 available yet "under the counter"? I haven't seen anything confirming that it actually works or that it's filtering out to the public.

I'm in contact with a doctor who claims he have been using it already on some guys and on himself, but I can't tell you if its true or not, the guy is quite precise on the action mechanism, on the effects and on the duration, that's why I'm provoking him proposing to do it to me, but sill nothing...

[eiweiss]

Something similar is ready.

[eiweiss]

It's a myostatin-vaccine.

[growingbigger]

ACVR2B is available from some companies now, but it is still extremely expensive. You'd need one gram to get any huge substantial growth out of it which would cost thousands.

The myostatin vaccine is also available in some parts of the world, but not in the U.S. it would seem. I would love to try either one of these.

[BIGJOEY]

only one pharma company controls the research for the myostain process. thats Squibb. to date they have not gone beyond the first round of testing. There is no myostatin vaccine on the market. what you are refering to is the product that claime to block myostatin in the body by using fertalized egg yolks. To date there is no research to support this claim.

[joxok]

Btw still searching here

[hrdcoach]

Hey guy I can't help you, but good luck finding what your looking for.

[bb_sponsor]

Are you still looking for a sponsor?

[joxok]

Originally Posted by bb_sponsor

Are you still looking for a sponsor?

Yes, more than ever, I just sent you a PM.

[MiMuscle]

Are you still looking? We are a gay couple in Ann Arbor, MI looking for share our home and passion for bodybuilding for a young, genetically gifted boy who we can GROW. It's fine to contact us at [email protected] for a faster response.

[joxok]

Just sent you an email message