Myostatin Update - Page 3

msclbldr · #81 November 26th, 2008, 12:39 PM

Although the major drug companies seem to have gone quiet over the development of anti muscle wasting treatments using myostatin blockers etc, it appears that the vetinerary companies have started development of various anti-myostatin protocols. One is working on a treatment for aging dogs to counteract the muscle wasting and "slowing down" that they suffer.

The cynics amongst us might suspect that this is a cover to develop a potentially very lucrative cosmetic and performance enhancing muscle building agent for humans. The australian vetinary pharmceutical industry produces many time more steroids than could legitimately be used, so where does the surplus go? I suspect that any canine anti myostatin treatment will go the same way. I also suspect that, due to the less stringent testing protocols required for vetinerary drug development, it will happen a lot sooner that we might otherwise suspect.

I shall be eagerly awaiting developments.

growinguysf · #82 November 14th, 2009, 05:30 PM

Success Boosting Monkey Muscle Could Help Humans

This was on NPR recently:

Copyright ? 2009 National Public Radio?. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.
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Heard on All Things Considered
November 11, 2009 - MICHELE NORRIS, host:
A few years ago, scientists created a genetically modified mouse with huge muscles. It became known as Mighty Mouse. Now, researchers have used a similar approach to produce muscle-bound monkeys.
As NPR's Jon Hamilton explains, this brings scientists a step closer to new treatments for people with diseases such as muscular dystrophy.
JON HAMILTON: All of this muscle research has to do with a substance called myostatin. Normally, myostatin in the body prevents muscles from getting too big. Take it away and muscles can become huge. So, researchers have been looking for a way to block the effects of myostatin in people with muscle-wasting diseases. You could do that with regular injections of a drug. Another way is to ramp up the body's own ability to block myostatin.
Brian Kaspar of Ohio State University is part of a team that's done that by putting an extra dose of genes right where they're needed.
Dr. BRIAN KASPAR (Professor of Pediatrics, Ohio State University): Our approach has been to develop a one-time gene delivery, given it's a simple shot into the muscle.
HAMILTON: And it works great in mice. But of course, lots of things that work in mice don't work in people.
Jerry Mendell is another member of the gene team. He directs the Center for Gene Therapy at Nationwide Children's Hospital in Columbus.
Dr. JERRY MENDELL (Director, Center for Gene Therapy, Nationwide Childrens Hospital): So, we decided that the best way to test our gene therapy model was to take it to the monkey. And if it worked, it had a better chance of working in patients.
HAMILTON: The team injected the right thigh muscles of six macaque monkeys. Kaspar says researchers didn't have to wait long.
Dr. KASPAR: We found that muscles started to get larger in circumference. And when we measured the strength generated out of those muscles, indeed the treated muscles were significantly higher than untreated muscles.
HAMILTON: The success means the team is ready to move on to people. Mendell says they want to begin with patients who have a disease called inclusion body myositis. It leaves thigh muscles so weak, people can't stand up.
Dr. MENDELL: If everything works out, we should be in a clinical trial by next summer.
HAMILTON: That would be a big step. But even cautious scientists have been impressed by the results in monkeys.
Dr. SE-JIN LEE (Professor of Molecular Biology and Genetics, Johns Hopkins University): Certainly very intriguing, very interesting, potentially very exciting.
HAMILTON: That's Se-Jin Lee of Johns Hopkins University. He's the scientist who discovered myostatin. Lee says many different groups have now found ways to manipulate the myostatin pathway and produce muscle growth in a wide range of animals. He says that bodes well for treating people.
Dr. LEE: Tampering with this pathway will probably work in terms of increasing muscle growth. You know, that still is hypothesis. It definitely has not been proven, but there are more and more signs that that probably will work.
HAMILTON: And not just on sick people. Athletes and bodybuilders have been following the research closely. Some of them are looking for a new kind of doping. Lee says it would be pretty hard for these would-be dopers to make drugs that block myostatin.
Dr. LEE: The scary part is that that's just not true in the case of gene therapy. It's a fairly easy thing for a, you know, a small group to set up and produce, and you only need to give essentially a single injection, presumably, or a limited number of injections and it's there forever.
HAMILTON: The World Anti-Doping Agency is already working on a test for this sort of doping. The new research appears in the journal Science Translational Medicine.
Jon Hamilton, NPR News.
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dallasmsl · #83 November 15th, 2009, 06:13 AM

Thanks for the information.

Ender · #84 November 16th, 2009, 09:52 PM

I they were working with Chimps or Bonobos rather than Macaques I would more excited... Their Genome is much closer to human... But they are also more costly to work with and the rules for their use in experiments are much more restrictive...

It's unclear from this article whether they were they were injected a myostantin blocker, a gene to produce a myostantin blocker or replace the gene for functional myostantin one the is inactive.Which ever is the case it appearers that the injection only affects the muscle injected... Ideal the gene would be inserted into the subject with a carrier Virus that affect every cell of the subject...

Also I understand that myostantin and or its blockers also affects the growth and maintenance of fat cells... what could be a significant problem is that fats are a major component in the construction of neurons. So using myostantin manipulation to enhance musculature could result is neurological damage... So it might not be a real good trade...

When they first tried to use Human Growth Hormone to help very short kids, with a hGH deficiency, get taller many contracted Creutzfeldt-Jakob Disease (the human equivalent of Mad Cow Disease) when the supplies of cadaver harvested hHG became contaiminated... Definitely not a good trade...

Ender

eiweiss · #85 November 18th, 2009, 04:27 AM

@Drew

The genes are identified, the methods to block myostatin effectively too. There are weekly publications about the different effects on cells and animals. But ethical comitees hinder the development on the human. The human is NOT an experiment. Frist, all the safety-trials need to be done and be proven, before they can move on human experimentation.
Gene Therapy is not that easy as it sounds.
The results of the Wyeth-Trial have been published and are available.

eiweiss · #86 November 18th, 2009, 04:28 AM

@Drew

The genes are identified, the methods to block myostatin effectively too. There are weekly publications about the different effects on cells and animals. But ethical comitees hinder the development on the human. The human is NOT an experiment. Frist, all the safety-trials need to be done and be proven, before they can move on human experimentation.
Gene Therapy is not that easy as it sounds.
The results of the Wyeth-Trial have been published and are available.

Ender · #87 November 18th, 2009, 01:07 PM

For what it's worth...

The human trails of MYO-029 were completed and March 11, 2008 Wyeth Pharmaceuticals announced that it won't develop MYO-029 for treatment of muscular dystrophy... Citing that although it was "found to be safe and well tolerated at three dosage levels" that " investigators found no improvements in muscle strength or function, and no statistically significant muscle growth in trial participants."

MYO-029, Stamulumab, is a recombinant human antibody designed to bind to and inhibit the activity of myostatin.

Ender

BIGJOEY · #88 November 18th, 2009, 05:38 PM

There is no myostation product out on the market right now. There have been a few studies and some research done by a few of the drug companies( wyeth) but they have not released all findings as of yet. Any supplement product sold at present that claims to be a myostatin blocker is not being honest and just taking your money. If your trying to build size it would be more advantageious for you to keep your cortisol levels down.

eiweiss · #89 November 19th, 2009, 04:17 AM

@ BigJoey

Agreed. Unless you're a bio-chemist and a medical doctor and you can produce and inject the si-RNA yourself

wolfotehmoon · #90 December 8th, 2009, 08:13 PM

Seems that there was a successful trial on using gene therapy to block myostatin in monkeys, with a 15% increase in quadriceps circumference in 15 weeks!

http://singularityhub.com/2009/12/08...-human-trials/

http://stm.sciencemag.org/content/1/...0-6363c0c4ba61

brawnybiguy · #91 December 9th, 2009, 03:03 PM

Wow, 15% increase in muscle circumference and 78% increase in strength in 12 weeks. Can you imagine increasing your squat by 78% in 3 months?

Ragetiger · #92 December 9th, 2009, 10:20 PM

Quote:

Originally Posted by brawnybiguy

Wow, 15% increase in muscle circumference and 78% increase in strength in 12 weeks. Can you imagine increasing your squat by 78% in 3 months?

Why stop there? I would kill for those kind of gains in curl or bench press! Can you imagine yourself blown up with all that newfound strength?

WhoDunIt · #93 December 10th, 2009, 10:44 PM

Sounds good to me Rage

IJrge · #94 April 5th, 2011, 10:46 AM

Anyone hear more about this?

dallasmsl · #95 April 5th, 2011, 10:51 AM

Nothing yet. I thought it was on the verge of coming to fruition but nothing yet.

Ragetiger · #96 April 5th, 2011, 02:48 PM

Haven't seen much about the blockers but there seems to be a inhibitor floating around. http://www.bodybuilding.com/store/bpt/myo-t-12.html

It's getting mixed reviews. Some getting results others not so much. For a hundred bones, it seems to be a high risk suppliment. I'm tempted to get this once I find a job... T_T curse my luck of job hunting.

dallasmsl · #97 April 5th, 2011, 03:43 PM

I have spent my money on it. It is a pure scam. The inventor says it takes three full months before you notice any results. He has a web site where only good feed back is allowed. Save your money. If it really worked, you would have heard about it already.

Ragetiger · #98 April 5th, 2011, 06:25 PM

Quote:

Originally Posted by dallasmsl

I have spent my money on it. It is a pure scam. The inventor says it takes three full months before you notice any results. He has a web site where only good feed back is allowed. Save your money. If it really worked, you would have heard about it already.

That's the thing with anything, including exercising in general. It takes time to get a result. There is no magic pill, it takes time and effort. But like i said before, it works with some people and won't for others.

dallasmsl · #99 April 5th, 2011, 06:37 PM

Well, great. Once you get that job, please feel free to throw your money away. Why should I be the only fool? It's actually cheaper to get real juice but experience is the best teacher. Best of luck.

Ragetiger · #**100** April 5th, 2011, 10:28 PM

Quote:

Originally Posted by dallasmsl

Well, great. Once you get that job, please feel free to throw your money away. Why should I be the only fool? It's actually cheaper to get real juice but experience is the best teacher. Best of luck.

Just cause it didn't work for you, doesn't mean it won't work for everybody. there's been plenty of proven cases that got exceptional results. It all falls down to your genes, nutrition and your workouts. Oddly enough, you probably would think the same about Yok3d.

You are sounding more and more like the person seeking the magic pill.